中国医学科学院肿瘤医院/分子肿瘤学国家重点实验室研究员，北京协和医学院长聘教授和“教学名师”，国家杰出青年科学基金获得者，卫生部有突出贡献的中青年专家。1982年安徽师范大学本科毕业，1988年皖南医学院硕士毕业，1993年法国克莱蒙第一大学博士毕业。
1995年应聘到中国医学科学院肿瘤医院/分子肿瘤学国家重点实验室工作。现为中华医学科技奖评审委员会委员，中国抗癌协会肿瘤病因学专业委员会和中华医学会医学遗传学分委会常委，《PROTEOMICS-Clinical Applications》、《Chinese Journal of Cancer Research》、《Chinese Journal of Cancer》、《J Thoracic Disease》、《World Journal of Clinical Oncology》、《中华肿瘤杂志》、《中华医学遗传学杂志》等杂志编委，《中国肺癌杂志》常务编委，《癌变畸变突变》和《国际遗传学杂志》杂志副主编。

长期从事肿瘤分子生物学和肿瘤遗传学工作，研究方向为癌变分子机理及肿瘤分子标志。近年负责的科研项目包括863重大专项、973计划、国家科技支撑计划、卫生行业科研专项、国家自然科学基金重点项目及面上项目、北京市科技计划重大专项、北京市自然科学基金、教育部高校博士学科点基金等。取得的主要学术成就包括：研究揭示了CTTN、CRT、PLK1、PKCiota、SKP2、Ln5-gamma2等多个调节细胞增殖、凋亡抗性、粘附、运动以及肿瘤侵袭转移的基因及其相关信号通路，鉴定了多个可能用于肿瘤癌前预警、早期诊断以及分型的分子标志，作为通讯和第一作者已在Nature Genetics、Gastroenterology、Cancer Research、Clinical Cancer Research、Cell Research、Oncogene、Carcinogenesis、Journal of Molecular Medicine、Molecular Cancer Research、International Journal of Cancer、Genes Chromosomes Cancer、European Journal of Cancer、Genomics、Cancer Letters、Gene等杂志发表英文学术论文60余篇，主编《肿瘤遗传学》和中华医学百科全书《肿瘤学》基础卷等专著，获得2013年国家科技进步奖一等奖，并多次获得北京市科学技术奖、中华医学科技奖和教育部高等学校自然科学奖。



近五年作为通讯作者发表的论文：

Shi F,Shang L, Pan BQ, Wang XM, Jiang YY, Hao JJ, Zhang Y, Cai Y, Xu X, Zhan QM, Wang MR*. Calreticulin promotesmigrationinvasion of esophageal cancer cells by up-regulating neuropilin-1expression via STAT5A. ClinCancer Res. 2014 Sep 17. [Epub ahead of print].

LiuYZ, Jiang YY, Wang BS, Hao JJ, Shang L, Zhang TT, Cao J, Xu X, Zhan QM, Wang MR*. A panel of protein markersfor the early detection of lung cancer with bronchial brushing specimens.Cancer Cytopathol. 2014 Jul 9. [Epub ahead of print].

ZhangTT, Jiang YY, Shang L, Shi ZZ, Liang JW, Wang Z, Zhang Y, Hao JJ, Jia XM, Xu X,Cai Y, Zhan QM, Wang MR*.Overexpression of DNAJB6 promotes colorectal cancer cell invasion through anIQGAP1/ERK-dependent signaling pathway. Mol Carcinog. 2014 Jul 7. [Epub ahead ofprint].

Hao JJ,Yao HQ,Dai GY,Kang W,Jia XM,Xu X,Cai Y,Zhan QM,Wang GQ,Wang MR*.Chromosomal aneuploidiescombinational fluorescence in situ hybridizationprobe panels are useful for predicting prognosis for esophageal squamous cellcarcinoma. J Gastroenterol. 2014 May 11. [Epub aheadof print]

ShangL, Liu HJ, Hao JJ, Jiang YY, Shi F, Zhang Y, Cai Y, Xu X, Jia XM, Zhan QM, Wang MR*. A Panel of OverexpressedProteins for Prognosis in Esophageal Squamous Cell Carcinoma. PLoS One. 2014Oct 22;9(10):e111045.

LinDC, Wang MR*, Koeffler HP. Targetinggenetics lesions in esophageal cancer. Cell Cycle. 2014 Jul1;13(13):2013-4.

ShiZZ, Jiang YY, Hao JJ, Zhang Y, Zhang TT, Shang L, Liu SG, Shi F, Wang MR*. Identification of putativetarget genes for amplification within 11q13.23q27.1 in esophageal squamous cell carcinoma. ClinTransl Oncol. 2014 Jul;16(7):606-15.

WangBS, Yang Y, Lu HZ, Shang L, Zhang Y, Hao JJ, Shi ZZ, Wang XM, Liu YZ, Zhan QM,Jia XM, Wang MR*. Inhibition ofatypical protein kinase Cι induces apoptosis through autophagic degradation ofβ-catenin in esophageal cancer cells. Mol Carcinog. 2014 Jul;53(7):514-25.

CheYQ, Liu P, Luo Y, Shen D, Hao JJ, Yang L, Zhang CG, Qi J, Wang MR*. Bcl-2/IgH expression of diffuse large B-cell lymphomacells in minimal bone marrow infiltration. Clin Lab. 2014;60(6):989-98.

Li N,Hou JL, Shi ZZ, Li XG, Li N, Sun YC, Xu X, Cai Y, Zhang X, Zhang KT, Wang MR*, Wu LY. Copy number changes of4-gene set may predict early relapse in advanced epithelial ovarian cancerafter initial platinum-paclitaxel chemotherapy. Am J Cancer Res. 2014 May26;4(3):285-92.

LinDC, Hao JJ, Nagata Y, Xu L, Shang L, Meng X, Sato Y, Okuno Y, Varela AM, DingLW , Garg M, Liu LZ, Yang H, Yin D, ShiZZ , Jiang YY, Gu WY, Gong T, Zhang Y, Xu X, Kalid O, Shacham S, Ogawa S, Wang MR*, Koeffler HP. Genomic andmolecular characterization of esophageal squamous cell carcinoma. NatureGenetics 2014 May;46(5):467-73.

ShiZZ, Shang L, Jiang YY, Hao JJ, Zhang Y, Zhang TT, Lin DC, Liu SG, Wang BS, GongT, Zhan QM, Wang MR*. Consistent anddifferential genetic aberrations between esophageal dysplasiasquamous cellcarcinoma detected by array comparative genomic hybridization. Clin Cancer Res.2013 Nov 1; 19(21):5867-78.

WangXM, Shang L, Zhang Y, Hao JJ, Shi F, Luo W, Zhang TT, Wang BS, Yang Y, Liu ZH,Zhan QM, Wang MR*. Protein-TyrosinePhosphatase 1B Contributes to Calreticulin-Induced Cell Migration andMetastasis of Esophageal Squamous Cell Carcinoma. Mol Cancer Res. 2013; 11(9):986-94.

WangBS, Yang Y, Yang H, Liu YZ, Hao JJ, Zhang Y, Shi ZZ, Jia XM, Zhan QM, Wang MR*. PKCι counteracts oxidativestress by regulating Hsc70 inan esophageal cancer cell line. Cell Stress Chaperones. 2013 May;18(3):359-66.

HaoJJ, Gong T, Zhang Y, Shi ZZ, Xu X, Dong JT, Zhan QM, Fu SB, Wang MR*. Characterization of generearrangements resulted from genomic structural aberrations in human esophagealsquamous cell carcinoma KYSE150 cells. Gene. 2013 Jan 15;513(1):196-201.

ShiZZ, Zhang YM, Shang L, Hao JJ, Zhang TT, Wang BS, Liang JW, Chen X, Zhang Y,Wang GQ, Wang MR*, Zhang Y*. Genomicprofiling of rectal adenomacarcinoma by array-based comparative genomichybridization. BMC Med Genomics. 2012 Nov 16;5:52(pp1-10).

WangBS, Liu YZ, Yang Y, Zhang Y, Hao JJ, Yang H, Wang XM, Zhang ZQ, Zhan QM, Wang MR*. Autophagy negativelyregulates cancer cell proliferation via selectively targeting VPRBP. ClinicalScience. 2013 Feb;124(3):203-14.

HaoJJ, Shi ZZ, Zhao ZX, Zhang Y, Gong T, Li CX, Zhan T, Cai Y, Dong JT, Fu SB,Zhan QM, Wang MR*. Characterizationof genetic rearrangements in esophageal squamous carcinoma cell lines by acombination of M-FISHarray-CGH: Further confirmation of some split genomicregions in primary tumors. BMC Cancer 2012; 12:367(pp1-17).

LiuYZ, Wang Z, Fang LL, Li L, Cao J,Xu X, Han YL, Cai Y, Wang LX, Wang MR*.A potential probe set of fluorescence in situ hybridization for detection oflung cancer in bronchial brushing specimens. J Cancer Res Clin Oncol. 2012Sep;138(9):1541-9.

LiuYZ, Jiang YY, Hao JJ, Lu SS, Zhang TT, Shang L, Cao J, Song X, Wang BS, Cai Y, ZhanQM, Wang MR*. Prognosticsignificance of MCM7 expression in the bronchial brushings of patients withnon-small cell lung cancer (NSCLC). Lung Cancer. 2012 Jul;77(1):176-82.

ZhangY, Du XL, Wang CJ, Lin DC, Ruan X, Feng YB, Huo YQ, Peng HY, Cui JL, Zhang TT, WangYQ, Zhang HB, Zhan QM, Wang MR*. Reciprocalactivation between PLK1Stat3 contributes to survivalproliferation of esophagealcancer cells. Gastroenterology. 2012 Mar;142(3):521-530.e3. [入选F1000]

LinDC, Zhang Y, Pan QJ, Yang H, Shi ZZ, Xie ZH, Wang BS, Hao JJ, Zhang TT, Xu X,Zhan QM, Wang MR*. PLK1 Istranscriptionally activated by NF-κB during cell detachmentenhancesanoikis resistance through inhibiting β-catenin degradation in esophagealsquamous cell carcinoma. Clin Cancer Res. 2011 Jul 1;17(13):4285-95.

ShiZZ, Liang JW, Zhan T, Wang BS, Lin DC, Liu SG, Hao JJ, Yang H, Zhang Y, ZhanQM, Zhang KT, Wang MR*. GenomicAlterations with Impact on Survival in Esophageal Squamous Cell CarcinomaIdentified by Array Comparative Genomic Hybridization. Genes Chromosomes Cancer2011 Jul; 50(7):518-26.

LiuSG, Wang BS, Jiang YY, Zhang TT, Shi ZZ, Yang Y, Yang YL, Wang XC, Lin DC,Zhang Y, Yang H, Cai Y, Zhan QM, Wang MR*.Atypical Protein Kinase C{iota} (PKCiota) Promotes Metastasis of EsophagealSquamous Cell Carcinoma by Enhancing Resistance to Anoikis viaPKC{iota}-SKP2-AKT Pathway. Mol Cancer Res. 2011 Apr; 9(4):390-402.

Du XL,Yang H, Liu SG, Luo ML, Hao JJ, Zhang Y, Lin DC, Xu X, Cai Y, Zhan QM, Wang MR*. Calreticulin promotes cellmotilityenhances resistance to anoikis through STAT3-CTTN-Akt pathway inesophageal squamous cell carcinoma. Oncogene. 2009 Oct 22; 28(42):3714-22.